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Important Safety Information | Prescribing Information
Esperoct antihemophilic factor (recombinant), glycopegylated-exei logo.
Esperoct® is used to treat and prevent or reduce the number of bleeding episodes in people with hemophilia A. See full indication below
 
Important Safety Information | Prescribing Information
Novoeight Antihemophilic Factor (Recombinant) logo.
Novoeight® is used to control and prevent bleeding in people with hemophilia A. See full indication below.
 
Take control of your hemophilia treatment journey
Photo of a woman smiling with the caption ‘Tammy lives with hemophilia A and uses Esperoct®’
Photo of a woman smiling with the caption ‘Tammy lives with hemophilia A and uses Esperoct®’
Learn how to self-advocate with your doctor to receive the care you need
When you’re a woman, girl, or female assigned at birth living with hemophilia A, finding a diagnosis and treatment options can be challenging.
Icon of a mother and daughter drawn in pink, standing together
Icon of a mother and daughter drawn in pink, standing together Up to half of women and girls who are carriers for the hemophilia gene are at risk for bleeding due to having factor levels below 50%, according to the National Bleeding Disorders Foundation. Some of these women and girls could have hemophilia A  
You know your body best. Learn how to recognize and document bleeds with our Self-Advocacy Guide.
 Become Your Best Advocate 
 
Keep scrolling to learn more
 
Esperoct® Selected Important Safety Information
Who should not use Esperoct®?
  • You should not use Esperoct® if you are allergic to factor VIII or any of the other ingredients of Esperoct® or if you are allergic to hamster proteins
What is the most important information I need to know about Esperoct®?
  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center
  • Call your healthcare provider right away or get emergency treatment right away if you get any signs of an allergic reaction, such as: hives, chest tightness, wheezing, dizziness, difficulty breathing, and/or swelling of the face
Novoeight® Selected Important Safety Information
Who should not use Novoeight®?
  • You should not use Novoeight® if you are allergic to factor VIII or any of the other ingredients of Novoeight® or if you are allergic to hamster proteins
What is the most important information I need to know about Novoeight®?
  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia center
  • Call your healthcare provider right away and stop treatment if you get any of the following signs of an allergic reaction: rashes or hives, difficulty breathing or swallowing, tightness of the chest, swelling of the lips and tongue, light-headedness, dizziness or loss of consciousness, pale and cold skin, fast heartbeat, or red or swollen face or hands
 
Flexxibility factorsa
made for you: Esperoct® and Novoeight®
It can be a challenge for some women to get appropriate treatment for hemophilia A, but you are the expert on your experience.
Numerical graphic that reads ‘48%’
Numerical graphic that reads ‘48%’ of the women and girls with the hemophilia gene or family history who visited a Hemophilia Treatment Center were diagnosed with hemophiliab  
Ask your doctor about getting the bleed protection you deserve with Esperoct® or Novoeight®:
Explore Esperoct®   Get to know Novoeight®
aPrior to reconstitution, Esperoct® and Novoeight® can be stored from 36 °F to 46 °F for up to 30 months, at room temperature up to 86 °F for up to 12 months, or up to 104 °F for up to 3 months. See Prescribing Information for complete product storage information.
bIn a real-world study of data collected from people receiving care in HTCs from 2012-2020.
 
  Photo of two RBCLs, Noberto and Lorie, standing side by side
Your Rare Blood Community Liaison (RBCL) is here to help.
Life with a bleeding disorder can bring challenges. Our RBCLs are experienced and ready to provide you with one-on-one support, including:
Information about Esperoct® and Novoeight®
Bleeding disorder & lifestyle education
Updates on local events
Tools to help you manage your bleeding disorder
 Reach out to your RBCL 
 
What is Esperoct®?
Esperoct® [antihemophilic factor (recombinant), glycopegylated-exei] is an injectable medicine to treat and prevent or reduce the number of bleeding episodes in people with hemophilia A. Your healthcare provider may give you Esperoct® when you have surgery
  • Esperoct® is not used to treat von Willebrand Disease
Important Safety Information
Who should not use Esperoct®?
  • You should not use Esperoct® if you are allergic to factor VIII or any of the other ingredients of Esperoct® or if you are allergic to hamster proteins
What is the most important information I need to know about Esperoct®?
  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center
  • Call your healthcare provider right away or get emergency treatment right away if you get any signs of an allergic reaction, such as: hives, chest tightness, wheezing, dizziness, difficulty breathing, and/or swelling of the face
What should I tell my healthcare provider before using Esperoct®?
  • Before taking Esperoct®, you should tell your healthcare provider if you have or have had any medical conditions, take any medicines (including non-prescription medicines and dietary supplements), are nursing, pregnant or planning to become pregnant, or have been told that you have inhibitors to factor VIII
  • Your body can make antibodies called “inhibitors” against Esperoct®, which may stop Esperoct® from working properly. Call your healthcare provider right away if your bleeding does not stop after taking Esperoct®
What are the possible side effects of Esperoct®?
  • Common side effects of Esperoct® include rash or itching, and swelling, pain, rash or redness at the location of infusion
Please click here for Prescribing Information.
Esperoct® is a prescription medication.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
What is Novoeight®?
Novoeight® (antihemophilic factor, recombinant) is an injectable medicine used to control and prevent bleeding in people with hemophilia A. Your healthcare provider may give you Novoeight when you have surgery
  • Novoeight® is not used to treat von Willebrand Disease
Important Safety Information
Who should not use Novoeight®?
  • You should not use Novoeight® if you are allergic to factor VIII or any of the other ingredients of Novoeight® or if you are allergic to hamster proteins
What is the most important information I need to know about Novoeight®?
  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia center
  • Call your healthcare provider right away and stop treatment if you get any of the following signs of an allergic reaction: rashes or hives, difficulty breathing or swallowing, tightness of the chest, swelling of the lips and tongue, light-headedness, dizziness or loss of consciousness, pale and cold skin, fast heartbeat, or red or swollen face or hands
What should I tell my healthcare provider before using Novoeight®?
  • Before taking Novoeight®, you should tell your healthcare provider if you have or have had any medical conditions, take any medicines (including non-prescription medicines and dietary supplements), are nursing, pregnant or planning to become pregnant, or have been told that you have inhibitors to factor VIII
  • Your body can make antibodies called “inhibitors” against Novoeight®, which may stop Novoeight® from working properly. Call your healthcare provider right away if your bleeding does not stop after taking Novoeight®
What are the possible side effects of Novoeight®?
  • Common side effects of Novoeight® include inhibitors in patients who were not previously treated with factor VIII products, swelling or itching at the location of injection, and fever
Please click here for Prescribing Information.
Novoeight® is a prescription medication.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
 
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Novo Nordisk Inc., 800 Scudders Mill Road, Plainsboro, New Jersey 08536 U.S.A.
Esperoct® and Novoeight® are registered trademarks of Novo Nordisk Health Care AG.
All other trademarks, registered or unregistered, are the property of their respective owners.
Novo Nordisk is a registered trademark of Novo Nordisk A/S.
© 2025 Novo Nordisk  All rights reserved.  US24ESP00101  March 2025
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