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| Indicated for congenital hemophilia A or B with inhibitors, congenital Factor VII deficiency, Glanzmann’s thrombasthenia with refractoriness to platelets, and acquired hemophilia. See full indication below. |
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| Sign up to stay up to date on the latest bleeding disorders news from novoMEDLINK™ |
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| Bleeds happen. Treat fast. |
| Having an on-demand agent on hand helps keep patients prepared to act quickly. |
| You may already know that MASAC recommends rFVIIa to treat acute bleeds in patients with congenital hemophilia A with inhibitors taking emicizumab prophylaxis.1 Explore how real-world results in patients with CHwI reinforce administering NovoSeven® RT early to resolve bleeds.2 |
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| Scroll to see if NovoSeven® RT is right for your patients. |
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| Selected Important Safety Information |
| WARNING: THROMBOSIS |
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Serious arterial and venous thrombotic events following administration
of NovoSeven® RT have been reported
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Discuss the risks and explain the signs and symptoms of thrombotic and
thromboembolic events to patients who will receive
NovoSeven® RT
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Monitor patients for signs or symptoms of activation of the coagulation
system and for thrombosis
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| Warnings and Precautions |
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Serious arterial and venous thrombotic events have been reported in clinical trials
and postmarketing surveillance
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Patients with congenital hemophilia receiving concomitant treatment with aPCCs
(activated prothrombin complex concentrates), older patients particularly with
acquired hemophilia and receiving other hemostatic agents, and patients with a
history of cardiac and vascular disease may have an increased risk of developing
thrombotic events
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| Please click here or scroll below for additional Important Safety Information. |
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| For all ages and 4 indications: rely on NovoSeven® RT3 |
| NovoSeven® RT is proven effective for bleed resolution and surgery across 4 indications: CHAwI or CHBwI, AH, CFVIId, and GT with refractoriness to platelets—more than any other agent in its category.3-6 |
| At home, on-the-go, and at the hospital, NovoSeven® RT is ready for your patients when it matters most. |
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| Discover personalized professional education on novoMEDLINK™. |
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| If you found this information useful and would like to receive more curated educational updates and product information, create your account on novoMEDLINK™. |
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| Indications and Usage |
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NovoSeven® RT (coagulation Factor VIIa, recombinant) is a coagulation factor
indicated for:
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Treatment of bleeding episodes and perioperative management in adults and children
with hemophilia A or B with inhibitors, congenital Factor VII (FVII)
deficiency, and Glanzmann’s thrombasthenia with refractoriness to platelet
transfusions, with or without antibodies to platelets
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Treatment of bleeding episodes and perioperative management in adults with acquired
hemophilia
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| Important Safety Information (cont’d) |
| Warnings and Precautions (cont’d) |
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Hypersensitivity reactions, including anaphylaxis, can occur with
NovoSeven® RT. Patients with a known hypersensitivity to mouse,
hamster, or bovine proteins may be at a higher risk of hypersensitivity reactions.
Discontinue infusion and administer appropriate treatment when hypersensitivity
reactions occur
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Factor VII deficient patients should be monitored for prothrombin time (PT) and
factor VII coagulant activity (FVII:C). If FVII:C fails to reach the expected level,
or PT is not corrected, or bleeding is not controlled after treatment with the
recommended doses, antibody formation may be suspected and analysis for antibodies
should be performed
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Laboratory coagulation parameters (PT/INR, aPTT, FVII:C) have shown no direct
correlation to achieving hemostasis
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| Adverse Reactions |
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The most common and serious adverse reactions in clinical trials are thrombotic
events. Thrombotic adverse reactions following the administration of
NovoSeven® RT in clinical trials occurred in 4% of patients with
acquired hemophilia and 0.2% of bleeding episodes in patients with congenital
hemophilia
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| Drug Interactions |
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Thrombosis may occur if NovoSeven® RT is administered
concomitantly with Coagulation Factor XIII
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Please click here for
Prescribing Information, including Boxed Warning.
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| 1. |
MASAC recommendation on the use and management of emicizumab-kxwh (Hemlibra®) for hemophilia A with and without inhibitors. MASAC Document #268. Accessed June 20, 2023.
https://www.hemophilia.org/healthcare-professionals/guidelines-on-care/masac-documents/masac-document-268-recommendation-on-the-use-and-management-of-emicizumab-kxwh-hemlibrar-for-hemophilia-a-with-and-without-inhibitors |
| 2. |
Demartis F, Batorava A, Chambost H, et al. Real-world early treatment with room temperature–stable recombinant factor VIIa in hemophilia A/B and inhibitors: SMART-7™ post hoc analyses. TH Open. 2017;1(2):e130-e138. |
| 3. |
NovoSeven RT. Package insert. Novo Nordisk Inc; 2020. |
| 4. |
FEIBA. Package insert. Baxter Healthcare Corporation; 2023. |
| 5. |
Obizur. Package insert. Baxter Healthcare Corporation; 2023. |
| 6. |
SEVENFACT. Package insert. HEMA Biologics; 2022. |
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NovoSeven® is a registered trademark of Novo Nordisk Health Care AG.
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All other trademarks, registered or unregistered, are the property of their respective owners.
© 2023 Novo Nordisk All rights reserved. US23NSVN00041 September 2023 |
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